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Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components

Tan Wen Siang. (2014) Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components.

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Abstract

The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs.

Item Type:Patent
Keyword:Recombinant plasmid; Immunogenic component
Faculty or Institute:Faculty of Biotechnology and Biomolecular Sciences
Application Number:PI2014702540
Filing Date:2014-09-09
ID Code:33963
Deposited By: Mohd Hafiz Che Mahasan
Deposited On:24 Apr 2015 21:38
Last Modified:24 Apr 2015 21:38

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