Optimized lipase catalyzed synthesis of adipate ester in a solvent-free system.
Chaibakhsh, Naz, Abdul Rahman , Mohd Basyaruddin, Abd. Aziz, Suraini, Basri, Mahiran, Salleh, Abu Bakar and Raja Abdul Rahman , Raja Noor Zaliha (2009) Optimized lipase catalyzed synthesis of adipate ester in a solvent-free system. Journal of Industrial Microbiology and Biotechnology, 36 (9). pp. 1149-1155. ISSN 1367-5435
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Immobilized Candida antarctica lipase-catalyzed esterification of adipic acid and oleyl alcohol was investigated in a solvent-free system (SFS). Optimum conditions for adipate ester synthesis in a stirred-tank reactor were determined by the response surface methodology (RSM) approach with respect to important reaction parameters including time, temperature, agitation speed, and amount of enzyme. A high conversion yield was achieved using low enzyme amounts of 2.5% w/w at 60C, reaction time of 438 min, and agitation speed of 500 rpm. The good correlation between predicted value (96.0%) and actual value (95.5%) implies that the model derived from RSM allows better understanding of the effect of important reaction parameters on the lipase-catalyzed synthesis of adipate ester in an organic solvent-free system. Higher volumetric productivity compared to a solvent-based system was also offered by SFS. The results demonstrate that the solvent-free system is efficient for enzymatic synthesis of adipate ester.
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