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Expression of killer cell immunoglobulin-like receptors (KIR) in sex-associated malignancies


Hassan, Norfarazieda and Lee, Le Jie and Tan, Jun Hao and Idris, Siti Zuleha and Mohd Ibrahim, Hishamshah and Osman, Raudhawati and Seow, Heng Fong and Mohtarrudin, Norhafizah and Andi Asri, Andi Anggeriana and Abdullah, Maha (2022) Expression of killer cell immunoglobulin-like receptors (KIR) in sex-associated malignancies. Malaysian Journal of Medicine and Health Sciences, 18 (4). pp. 96-103. ISSN 2636-9346


Introduction: Sex shapes immune response with possible consequence on tumor immune escape. Acute lymphoblastic leukemia (ALL) predominates in males while ovarian cancer (OC) occurs in females. NK cells essential for tumor killing may have male preponderance. Association of sex, NK cell activity and malignancies is unclear. We hypothesize that sex differentially affects KIR expressions in sex-biased cancers. Method: Expression of inhibitory (KIR2DL1-5 and KIR3DL1-3) and activating (KIR2DS1-2 and 4-5 and KIR3DS1) genes in B-, T-cell ALL, OC and normal controls were determined by reverse-transcription polymerase-chain-reaction. Result: All normal males (but not females) expressed the framework genes and generally maintained haplotype A, except KIR3DL1. Normal females expressed more activating KIRs. Frequencies of KIR2DL1, 2DL4 and 2DS2 were significantly reduced among ovarian cancer patients. Sex difference in frequencies of KIR expression was not detected in ALL as majority were undetectable except framework gene KIR3DL2, was more frequent among T-ALL. Conclusion: Cancers may be associated with reduced KIR expression and influence of sex requires investigation.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.47836/mjmhs.18.4.14
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Sex; NK cells; Killer-cell immunoglobulin-like receptors (KIR); Acute lymphoblastic leukemia (ALL); Ovarian cancer (OC)
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 07 Nov 2022 09:09
Last Modified: 07 Nov 2022 09:09
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.47836/mjmhs.18.4.14
URI: http://psasir.upm.edu.my/id/eprint/98684
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