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Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients


Ibrahim, Izzaidah and Wan Mohamed, Wan Mohd Izani and Kah, Keng Wong and Tuan Ismail, Tuan Salwani and Wan Ghazali, Wan Syamimee (2022) Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients. Malaysian Journal of Medicine and Health Sciences, 18 (2). pp. 20-25. ISSN 1675-8544; ESSN: 2636-9346


Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level among SLE patients and its association with SLE Disease Activity (SLEDAI) scores and among groups of steroid and non-steroid usage. Methods: We recruited 84 SLE patients who attended the Rheumatology Clinic of Hospital Universiti Sains Malaysia from June 2018 until October 2018. Their clinico-demographic data were retrieved and serum vitamin D immunoassay was conducted to measure the vitamin D levels of each patient Vitamin D levels were categorized as normal (≥75nmol/L), insufficient (50-74 nmol/L) or deficient (<50 nmol/L). Comparison between the clinico-demographic parameters with vitamin D levels were conducted using the Fisher’s exact test (for categorical variables) and unpaired t-test (for continuous variables). Results: The mean vitamin D level among the subjects was 40.79 ± 20.2 nmol/L. Fifty-eight (69%) patients were vitamin D deficient, while 20 (23.8%) patients were vitamin D insufficient, and only 6 (7.1%) patients had sufficient level of vitamin D. Vitamin D status was not significantly associated with SLEDAI score (p=0.185) as well as between steroids and non-steroids groups (p=0.255). Conclusion: Vitamin D deficiency occurred in majority of our SLE patients. SLE disease activities were not associated with the status of vitamin D or steroid usage.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Systemic lupus erythematosus; SLEDAI score; Vitamin D; Steroids
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 11 Aug 2022 08:29
Last Modified: 11 Aug 2022 08:29
URI: http://psasir.upm.edu.my/id/eprint/98128
Statistic Details: View Download Statistic

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