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Hybrid nerve sheath tumour, a conglomerate of separate entities


Omar, Noorjehan and Mohd Dusa, Noraini and Bakhrin, Ikmal Hisyam and Omar, Noor Azzizah and Vasavan, Yabitha (2021) Hybrid nerve sheath tumour, a conglomerate of separate entities. Malaysian Journal of Medicine and Health Sciences, 17 (suppl.10). 111 - 114. ISSN 2636-9346


Hybrid nerve sheath tumours (HNSTs) are benign tumours showing combined features of more than one peripheral nerve sheath tumour (PNST) entities. Most literature highlight combination of two entities. Only few reported cases involve all three components of PNST. Herein, we report a case of 33-year-old Malay lady, with left proximal middle finger soft tissue swelling for three months. Microscopically, the tumour is well-circumscribed, containing all three components of PNST, with each displaying its typical morphology and immunohistochemical staining pattern. This case suggests that PNSTs may be more closely related than what was earlier believed. However, whether HNSTs are part of the PNSTs spectrum with tumour syndromes association or a distinct entity is still a continuous debate. We also highlight the possibilities of recurrence and risk of malignant transformation in HNSTs. The exact pathogenesis, potential for recurrence and malignant transformation criteria for HNSTs are still vague due to their extreme rarity.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Universiti Putra Malaysia
Keywords: Hybrid nerve sheath tumour; NF1; NF2; Schwannomatosis; PNST; MPNST
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 27 Jul 2022 01:47
Last Modified: 27 Jul 2022 01:47
URI: http://psasir.upm.edu.my/id/eprint/97577
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