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Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction


Citation

Abdul Latiff, Norliza and Pei, Ying Ong and Abd Rashid, Siti Nor Azlina and Abdullah, Luqman Chuah and Mohd Amin, Nor Amaiza and Mohd Fauzi, Noor Akhmazillah (2021) Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction. Scientific Reports, 11 (1). art. no. 17297. pp. 1-12. ISSN 2045-2322

Abstract

Cosmos caudatus (C. caudatus) is a medicinal plant that is high in bioactive compounds such as phenolics. In this study, an ultrasound extraction method was used to optimise the extraction of bioactive compounds from C. caudatus leaves. Response surface methodology (RSM) based on a Box-Behnken design (BBD) was applied to obtain the optimum extraction parameters which is solid–liquid ratio (10–30 g/mL), particle size (180–850 µm) and extraction time (20–30 min) for maximal quercitrin and total phenolic content (TPC) yields. Analysis of antimicrobial activity was performed against two human pathogenic microbes: Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) by the agar well diffusion method. The optimal ultrasonic extraction condition was as follow: solvent-liquid ratio of 1:28 (g/mL), particle size of 485 µm, and duration of 30 min, respectively. Remarkably, extraction using ultrasonic method had recovered more bioactive content and antioxidant activity than the Soxhlet method. The extract also exhibited good antimicrobial activities. Due to the above findings, the ultrasonic extraction was found to be suitable to improve recovery extraction of quercitrin and TPC from C. caudatus leaves. It also opens the possibility that the plant extract can be used for functional food and antimicrobial agents in various applications.


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Official URL or Download Paper: https://www.nature.com/articles/s41598-021-96623-x

Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.1038/s41598-021-96623-x
Publisher: Nature Portfolio
Keywords: Cosmos caudatus; Medicinal plant; Anti-infammatory
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 15 Oct 2022 14:35
Last Modified: 15 Oct 2022 14:35
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1038/s41598-021-96623-x
URI: http://psasir.upm.edu.my/id/eprint/97108
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