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A review on biological properties and synthetic methodologies of Diarylpentadienones


Citation

Abdullah, Maryam Aisyah and Mohd Faudzi, Siti Munirah and Mad Nasir, Nadiah (2021) A review on biological properties and synthetic methodologies of Diarylpentadienones. Mini-Reviews in Medicinal Chemistry, 21 (9). 1058 - 1070. ISSN 1389-5575; ESSN: 1875-5607

Abstract

Medicinal chemists have continuously shown interest in new curcuminoid derivatives, diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia- Kocienski olefination have been utilised for the synthesis of these compounds. Diarylpentadienones possess a high potential as a chemical source for designing and developing new and effective drugs for the treatment of diseases, including inflammation, cancer, and malaria. In brief, this review article focuses on the broad pharmacological applications and the summary of the structure-activity relationship of molecules, which can be employed to further explore the structure of diarylpentadienone. The current methodological developments towards the synthesis of diarylpentadienones are also discussed.


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Official URL or Download Paper: https://www.eurekaselect.com/article/112045

Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.2174/1389557520999201203213957
Publisher: Bentham Science
Keywords: Diarylpentadienone; SAR.; Bioactivity; Catalysts; Pharmacological activity; Synthesis
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 08 Mar 2023 07:16
Last Modified: 08 Mar 2023 07:16
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/1389557520999201203213957
URI: http://psasir.upm.edu.my/id/eprint/96036
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