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Anti-pyretic activity of two varieties of Hibiscus Rosa Sinensis L.


Abdul Aziz, Muhammad Wahizul Haswan and Raduan, Siti Zaleha and Abd Hamid @ Abdul Razak, Roslida and Zakaria, Zainul Amiruddin and A., Zuraini and Abdullah, Muhammad Nazrul Hakim (2021) Anti-pyretic activity of two varieties of Hibiscus Rosa Sinensis L. Biomedical and Pharmacology Journal, 14 (1). pp. 61-74. ISSN 0974-6242; ESSN: 2456-2610


Hibiscus rosa-sinensis has been traditionally used by local communities to treat fever. However, there are only limited data have been published to support the antipyretic effects. The objective of this study is to investigate the antipyretic properties and possible mechanism of the ethanol extracts of Hibiscus rosa-sinensisL. (red colored flower) and Hibiscus rosa-sinensisvar. Alba (white colored flower). Phytochemical analysis, heavy metals screening and acute toxicity test were done to evaluate the safety of extracts. The first model ran induced fever in rats by injecting Brewer's Yeast subcutaneously and then treated with 4 extracts at dosage 5 & 50 mg/kg. The dosages used for the study were obtained by the acute toxicity test. Ibuprofen was used as a reference drug, with dose 100 mg/kg. Temperatures of rats were measured using a digital thermometer. The results were expressed as mean ± S.E.M. and analyzed using the SAS system. The results of the study showed that white flower extract 5mg/kg and 50 mg/kg significantly (p <0.05) reduced the total temperature when compared to positive control group. Therefore, this research suggests the probability for its therapeutic effectiveness as plant-based antipyretic agent as claimed by traditional medicine practitioners.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.13005/bpj/2099
Publisher: Oriental Scientific Publishing
Keywords: Antipyretic; Hibiscus Rosa-Sinensis; Toxicity
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 26 Jan 2023 01:35
Last Modified: 26 Jan 2023 01:35
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.13005/bpj/2099
URI: http://psasir.upm.edu.my/id/eprint/95935
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