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Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review


Khan, Rahim and Mohamad Ghazali, Farinazleen and Mahyudin, Nor Ainy and Samsudin, Nik Iskandar Putra (2021) Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review. Journal of Fungi, 7 (8). art. no. 606. pp. 1-20. ISSN 2309-608X


Aflatoxins (AFs) are highly toxic and cancer-causing compounds, predominantly synthesized by the Aspergillus species. AFs biosynthesis is a lengthy process that requires as minimum as 30 genes grouped inside 75 kilobytes (kB) of gene clusters, which are regulated by specific transcription factors, including aflR, aflS, and some general transcription factors. This paper summarizes the status of research on characterizing structural and regulatory genes associated with AF production and their roles in aflatoxigenic fungi, particularly Aspergillus flavus and A. parasiticus, and enhances the current understanding of AFs that adversely affect humans and animals with a great emphasis on toxicity and preventive methods.

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Official URL or Download Paper: https://www.mdpi.com/2309-608X/7/8/606

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Halal Products Research Institute
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.3390/jof7080606
Publisher: Multidisciplinary Digital Publishing Institute
Keywords: Aflatoxins; Biosynthetic pathway; Genetic regulation; Toxicity; Control strategies
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 06 Apr 2023 07:53
Last Modified: 06 Apr 2023 07:53
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/jof7080606
URI: http://psasir.upm.edu.my/id/eprint/95738
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