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Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka


Hassan, Ibrahim Maina and Wan Ibrahim, Wan Norhamidah and Mohamat Yusuf, Ferdaus and Ahmad, Siti Aqlima and Ahmad, Syahida (2021) Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka. Pakistan Journal of Pharmaceutical Sciences, 34 (1). art. no. 7. 47 - 56. ISSN 1011-601X


Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in high demand. Therefore, the main purposed of this study is to evaluate the neuroprotective effects of Curcuma longa (rhizome) 80% methanol extract. Antioxidant using dichlorofuoresence diacetate (DCF-DA) assay on SH-SY5Y cells revealed high activities of Curcuma longa (rhizome) extract with IC50 of 105.9±0.8 µg/mL. Sub-acute and chronic toxicity tests of the plant extract on adult Javanese medaka (Oryzias javanicus) showed high toxicity effect with LC50 of 24.15±0.8 mg/L and 13.69±0.7 mg/L respectively. Neuroprotective tests using cholinesterase assay disclose significant differences at P<0.05 between the group that are exposed to arsenic and treated with the crude extract and the group that are exposed to only arsenic. Identification of vitexin and isovitexin justified the high antioxidant potential of this plant leaf and it highest benefit to be used as medicinal supplement.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Environmental Studies
Faculty of Science
DOI Number: https://doi.org/10.36721/PJPS.2021.34.1.REG.047-056.1
Publisher: Pakistan Journal of Pharmaceutical Sciences
Keywords: Antioxidants; Cancer; Epidemiologically; Neuroprotective; Oxidative stress.
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 07 Apr 2023 03:47
Last Modified: 07 Apr 2023 03:47
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.36721/PJPS.2021.34.1.REG.047-056.1
URI: http://psasir.upm.edu.my/id/eprint/94348
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