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Nanotechnology-based strategies for berberine delivery system in cancer treatment: pulling strings to keep berberine in power


Iqbal, Muhammad Javed and Quispe, Cristina and Javed, Zeeshan and Haleema Sadia and Qadri, Qamar Raza and Raza, Shahid and Salehi, Bahare and Martins, Natália Cruz and Abdulwanis Mohamed, Zeinab and Jaafaru, Mohammed Sani and Abdull Razis, Ahmad Faizal and Sharifi-Rad, Javad (2021) Nanotechnology-based strategies for berberine delivery system in cancer treatment: pulling strings to keep berberine in power. Frontiers in Molecular Biosciences, 7. art. no. 624494. pp. 1-12. ISSN 2296-889X


Cancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a limited cytotoxicity; therefore, can aid in the development of new therapeutic interventions for the treatment of this versatile disease. Berberine is a member of the protoberberine alkaloids family, mainly present in the root, stem, and bark of various trees, and has a reputed anticancer activity. Nonetheless, the limited bioavailability and low absorption rate are the two major hindrances following berberine administration as only 0.5% of ingested berberine absorbed in small intestine while this percentage is further decreased to 0.35%, when enter in systemic circulation. Nano-based formulation is believed to be an ideal candidate to increase absorption percentage as at nano scale level, compounds can absorb rapidly in gut. Nanotechnology-based therapeutic approaches have been implemented to overcome such problems, ultimately promoting a higher efficacy in the treatment of a plethora of diseases. This review present and critically discusses the anti-proliferative role of berberine and the nanotechnology-based therapeutic strategies used for the nano-scale delivery of berberine. Finally, the current approaches and promising perspectives of latest delivery of this alkaloid are also critically analyzed and discussed.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.3389/fmolb.2020.624494
Publisher: Frontiers Research Foundation
Keywords: Alkaloids; Berberine; Anticancer; Nanodelivery systems; Chemopreventive effects
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 05 Apr 2023 02:29
Last Modified: 05 Apr 2023 02:29
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3389/fmolb.2020.624494
URI: http://psasir.upm.edu.my/id/eprint/94327
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