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Updates on molecular and biochemical development and progression of prostate cancer


Fahmy, Omar and A. Alhakamy, Nabil and Y. Rizg, Waleed and Bagalagel, Alaa and J. Alamoudi, Abdulmohsin and M. Aldawsari, Hibah and M. Khateb, Aiah and M. Eldakhakhny, Basmah and A. Fahmy, Usama and H. Abdulaal, Wesam and G. Fresta, Claudia and Caruso, Giuseppe (2021) Updates on molecular and biochemical development and progression of prostate cancer. Journal of Clinical Medicine, 10 (21). pp. 1-13. ISSN 2077-0383


Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment.

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Official URL or Download Paper: https://www.mdpi.com/2077-0383/10/21/5127

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/jcm10215127
Publisher: MDPI
Keywords: Prostate cancer progression and tumorigenesis; Biomarkers; Growth factors; Inflammation; Oxidative stress; Androgen deprivation therapy
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 13 Jan 2023 03:33
Last Modified: 13 Jan 2023 03:33
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/jcm10215127
URI: http://psasir.upm.edu.my/id/eprint/93493
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