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Necrotizing autoimmune myopathy: a case series


Sulaiman Sahari, Narisa and Marwan, Abdul Aziz and Suahilai, Dayang Masyrinartie and Mohd Jamid, Nurulraziquin and Shahril, Nor Shuhaila (2020) Necrotizing autoimmune myopathy: a case series. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 8). pp. 78-80. ISSN 1675-8544; ESSN: 2636-9346


Necrotizing autoimmune myopathy (NAM) is considered a new subgroup of a rare autoimmune idiopathic inflammatory myopathies. Classically, NAM presented with sub-acute onset of proximal muscle loss of power with raised creatinine kinase and characteristic muscle biopsy showing muscle necrosis and regeneration with little inflammation. Statin use, connective tissue diseases, malignancy and HIV infection are the identified risk factors for NAM. The autoantibodies expected to be presented in NAM are anti-signal recognition particle (SRP) and anti-hydroxymethylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. In this article, we present three cases of NAM with different risk factors and autoantibodies which we believe to have impact on the clinical course and outcome of our patients.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Idiopathic inflammatory myopathies; Necrotizing autoimmune myopathy; Antibodies
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 09 Sep 2021 23:22
Last Modified: 09 Sep 2021 23:22
URI: http://psasir.upm.edu.my/id/eprint/90297
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