UPM Institutional Repository

Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity


Mohan, Subhatharshni and Abdul Rahim, Nazatul Shima and Salleh, Amizatul Aini and Mahayidin, Hasni and Bakrin, Ikmal Hisyam (2020) Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 127-130. ISSN 1675-8544; ESSN: 2636-9346


Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic dermatological features including non-bullous manifestations and blisters. Therefore, a wide range of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS) which has led to withdrawal of his oral chemotherapy treatment.

Download File

[img] Text

Download (752kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Bullous pemphigoid; Paraneoplastic; Hand-foot syndrome
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 09 Sep 2021 21:22
Last Modified: 09 Sep 2021 21:22
URI: http://psasir.upm.edu.my/id/eprint/90201
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item