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Prolonged neonatal jaundice with deranged thyroid function test


Choo, Jin Earn and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna (2020) Prolonged neonatal jaundice with deranged thyroid function test. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 117-119. ISSN 1675-8544; ESSN: 2636-9346


Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low or normal TSH levels after excluding all other causes of discordant thyroid function test (TFT). Here, we report a case of a baby girl who presented with prolonged jaundice at day 15 of life with normal cord blood TSH performed as routine screening for congenital hypothyroidism. Serial TFT revealed declining serum fT4 with normal TSH consistent with CCH. Her jaundice resolved prior to levothyroxine replacement. CCH is commonly missed on cord blood TSH-based newborn screening leading to a delay in diagnosis, potentially resulting in neurodevelopmental delay. Hence, although CCH has a lower incidence than congenital primary hypothyroidism, a high index of suspicion is essential for timely diagnosis.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Prolonged neonatal jaundice; Congenital central hypothyroidism; Thyroid function test; Newborn screening
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 09 Sep 2021 11:29
Last Modified: 09 Sep 2021 11:29
URI: http://psasir.upm.edu.my/id/eprint/90198
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