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Identify human cluster of differentiation 147 (CD147), a new target of SARS-CoV-2 invasion


Al-Salih, Moatasem and Samsudin, Syakirah and Al-Salih, Seenaa Wdaah and Arshad, Siti Suri and Warid, Fouad and Sfoog, Asaad Abdullah and Abed, Ryiah E. and Roomi, Ali B. (2020) Identify human cluster of differentiation 147 (CD147), a new target of SARS-CoV-2 invasion. International Journal of Phamaceutical Research, 12 (2). 2654 - 2667. ISSN 0975-2366


Objective: to determine the level of blood markers of cellular Human Cluster of Differentiation 147 (CD147) by ELISA assay. Immunological system, establishing the profile in patientsSARS-CoV-2 invades host cells via a novel route CD147-spike protein. Methods: a case-control study including 30 patients (10 female) with SARS-CoV-2 repertory disorder whose follow-up was carried out at the outpatient clinic of the intensive care unit Service at Al Hussain Hospital, southern of Iraq, Patients were divided into three subgroups based on the onset of symptoms within the first 6 days of the acute phase of disease subgroup A, subgroup B, and C. according to the type of drugs. Main systemic subgroup. Treatment group included 60 outpatients (25 female) being submitted to follow-up at the same hospital for non-inflammatory diseases. For determined the plasmatic levels of Human Cluster of Differentiation 147 (CD147), groups of S proteins Results: To start with, in vitro antiviral tests showed Meplazumab, infliximab and Etrolizumab an foe of CD147 adapted neutralizer, essentially hindered the infections from attacking host cells in comparison to controls, patients with presented concentrations of CD147 products (determined by plasmatic levels of S protein circulating in blood. Conclusion: our results indicate the presence of molecular SARS-CoV-2 invades respiratory cells determined by assay in patients which confirm a decrease in the defense capacity of the cellular system against toxicity induced by drugs in these patients.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Association of Indian Pharmacist
Keywords: SARS-CoV-2; Blood markers ; Human cluster; Spike protein
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 03 Nov 2021 06:49
Last Modified: 03 Nov 2021 06:49
URI: http://psasir.upm.edu.my/id/eprint/89262
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