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Exploring the potential use of Hylocereus polyrhizus peels as a source of cosmeceutical sunscreen agent for its antioxidant and photoprotective properties


Citation

Vijayakumar, Ramya and Abd Gani, Siti Salwa and Zaidan, Uswatun Hasanah and Halmi, Mohd Izuan Effendi and Karunakaran, Thiruventhan and Hamdan, Mohd Razak (2020) Exploring the potential use of Hylocereus polyrhizus peels as a source of cosmeceutical sunscreen agent for its antioxidant and photoprotective properties. Evidence-based Complementary and Alternative Medicine, 2020. art. no. 7520736. pp. 1-12. ISSN 1741-427X; ESSN: 1741-4288

Abstract

Currently, consumers’ demand for sunscreens derived from natural sources that provide photoprotection from ultraviolet (UV) radiation is pushing the cosmetic industry to develop breakthrough formulations of sun protection products by incorporating plant antioxidants as their active ingredients. In this context, the present study was initiated to evaluate the antioxidant and photoprotective properties of the underutilized Hylocereus polyrhizus peel extract (HPPE) using in vitro spectrophotometric techniques. The phytochemical screenings of HPPE conducted via high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) revealed the presence of phenolic acids and flavonoids as the major secondary metabolites in HPPE. The antioxidant potentials evaluated based on 2, 2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and total antioxidant capacity assays were in the range of 22.16 ± 0.24%–84.67 ± 0.03% with 50% inhibitory concentration (IC50) of 36.39 ± 0.04 μg/mL and 23.76 ± 0.14%–31.87 ± 0.26% (IC50 = 21.93 ± 0.07 μg/mL), respectively. For the photoprotective evaluation, the results showed that HPPE had significantly high absorbance values (3.1–3.6) at 290–320 nm with an exceptional sun protection factor (SPF) value of 35.02 ± 0.39 at 1.00 mg/mL. HPPE also possessed a broad-spectrum shielding power against both UVA and UVB radiations. Hence, in terms of practical implications, our findings would offer an exciting avenue to develop a photoprotective formulation incorporating the ethanolic extract of Hylocereus polyrhizus peels as a synergistic active ingredient for its excellent UV absorption properties and the strong antioxidant activities.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Biotechnology and Biomolecular Sciences
Halal Products Research Institute
DOI Number: https://doi.org/10.1155/2020/7520736
Publisher: Hindawi Publishing
Keywords: Ultraviolet; Hylocereus genus; Mass spectrometry; Sunscreen
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 04 Oct 2021 23:58
Last Modified: 04 Oct 2021 23:58
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2020/7520736
URI: http://psasir.upm.edu.my/id/eprint/88924
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