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Effects of zinc oxide nanoparticles on regulatory appetite and heat stress protein genes in broiler chickens subjected to heat stress


Ramiah, Suriya Kumari and Awad, Elmutaz Atta and Mohd Hemly, Nur Izzah and Ebrahimi, Mahdi and Omolayo, Olubodun Joshua and Jamshed, Muhammad and Saminathan, Mookiah and Soleimani, Abdoreza Farjam and Idrus, Zulkifli (2020) Effects of zinc oxide nanoparticles on regulatory appetite and heat stress protein genes in broiler chickens subjected to heat stress. Journal of Animal Science, 98 (10). pp. 1-8. ISSN 0021-8812; ESSN: 1525-3163


This study was conducted to explore the effect of the zinc oxide nanoparticles (ZnONPs) supplement on the regulatory appetite and heat stress (HS) genes in broiler chickens raised under high or normal ambient temperatures. In this study, 240 one-day-old male broiler chicks (Cobb 500) were randomly assigned to 48 battery cages. From day 1, these 48 cages were randomly subjected to four different treatment strategies: Control (wherein, their basal diet included 60 mg/kg of ZnO), ZNONPs 40 (wherein basal diet included 40 mg/kg of ZnONPs), ZnONPs 60 (basal diet included 60 mg/kg of ZnONPs), and ZnONPs 100 (basal diet included 100 mg/kg of ZnONPs). Thereafter, from day 22 to 42, the chickens from each dietary treatment group were subjected to different temperature stresses either normal (23 ± 1 °C constant) or HS (34 ± 1 °C for 6 h/d), which divided them into eight different treatment groups. Our findings revealed that dietary ZnONPs altered the gene expression of cholecystokinin (ileum), heat stress proteins (HSP) 70 (jejunum and ileum), and HSP 90 (duodenum, jejunum, and ileum). The gene expression of ghrelin was affected by the interaction between the ZnONPs concentration and temperature in the duodenum and stomach. More studies are required to elucidate its complex physiological and biochemical functions of the regulation of gene expression within the intestine in heat-stressed broiler chickens.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Veterinary Medicine
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.1093/jas/skaa300
Publisher: American Society of Animal Science
Keywords: Zinc oxide; Broiler chicken; Heat; stress
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 06 Oct 2021 03:25
Last Modified: 06 Oct 2021 03:25
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1093/jas/skaa300
URI: http://psasir.upm.edu.my/id/eprint/88742
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