UPM Institutional Repository

Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review


Venkatachalam, Karthikkumar and Vinayagam, Ramachandran and Anand, Mariadoss Arokia Vijaya and Mat Isa, Nurulfiza and Ponnaiyan, Rajasekar (2020) Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review. Toxicology Research, 9 (1). pp. 2-18. ISSN 2045-452X; ESSN: 2045-4538


1,2-dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon cancer in animal models. Exploration of DMH-induced colon carcinogenesis in rodent models provides the knowledge to perceive the biochemical, molecular, and histological mechanisms of different stages of colon carcinogenesis. The procarcinogen DMH, after a series of metabolic reactions, finally reaches the colon, there produces the ultimate carcinogen and reactive oxygen species (ROS), which further alkylate the DNA and initiate the development of colon carcinogenesis. The preneolpastic lesions and histopathological observations of DMH-induced colon tumors may provide typical understanding about the disease in rodents and humans. In addition, this review discusses about the action of biotransformation and antioxidant enzymes involved in DMH intoxication. This understanding is essential to accurately identify and interpret alterations that occur in the colonic mucosa when evaluating natural or pharmacological compounds in DMH-induced animal colon carcinogenesis.

Download File

[img] Text (Abstract)

Download (5kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1093/toxres/tfaa004
Publisher: Royal Society of Chemistry
Keywords: Colon cancer; DMH; Preneoplastic lesions; Chemoprevention
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 24 May 2022 04:47
Last Modified: 24 May 2022 04:47
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1093/toxres/tfaa004
URI: http://psasir.upm.edu.my/id/eprint/88023
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item