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Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds


Wu, Yong-Xiang and You, Jeong Kim and Tae, Hyung Kwon and Tan, Chin Ping and Kun, Ho Son and Kim, Taewan (2020) Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds. Natural Product Research, 34 (12). 1786 - 1790. ISSN 1478-6419; ESSN: 1478-6427


Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1080/14786419.2018.1527832
Publisher: Taylor and Francis
Keywords: Mulberry root bark; Anti-inflammatory; Diels-Alder type adducts; Albanol B
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 06 Jul 2022 05:02
Last Modified: 06 Jul 2022 05:02
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/14786419.2018.1527832
URI: http://psasir.upm.edu.my/id/eprint/87700
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