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Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability


Mohd Zaffarin, Anis Syauqina and Shiow, Fern Ng and Ng, Min Hwei and Hassan, Haniza and Alias, Ekram (2020) Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability. International Journal of Nanomedicine, 2020 (15). 9961 - 9974. ISSN 1176-9114


Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.2147/IJN.S276355
Publisher: Dove Press
Keywords: Tocopherols; Tocotrienols; Nanoparticles; Drug delivery; Bioavailability
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 18 Jan 2023 04:43
Last Modified: 25 Jan 2023 08:36
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S276355
URI: http://psasir.upm.edu.my/id/eprint/87139
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