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Loss of interleukin17RA expression is associated with tumour progression in colorectal carcinoma


Chai, Boon Yean and Yip, Wai Kien and Dusa, Noraini and Mohtaruddin, Norhafizah and Seow, Heng Fong (2020) Loss of interleukin17RA expression is associated with tumour progression in colorectal carcinoma. Pathology & Oncology Research, 26 (4). 2291 - 2298. ISSN 1219-4956; ESSN: 1532-2807


Interleukin-17 (IL-17) is a pro-inflammatory cytokine found in various cancers. Current evidence indicates that IL-17 plays a vital role in tumour initiation and progression in colorectal carcinoma (CRC) via binding with its receptor, IL-17RA. However, the association between clinicopathological features and presence of IL-17 and IL-17RA protein in primary CRC tissues remains unclear. This study also investigates the difference between the presence of IL-17 and IL-17RA in the paired tumour tissues versus adjacent normal tissues. The presence of IL-17RA and IL-17 protein in primary CRC tissues was determined by immunohistochemistry. Associations between clinicopathological features and IL-17RA and IL-17 immunoreactivity, were analyzed by χ2 tests. We found that both IL-17RA (p = 0.001) and IL-17 (p = 0.025) in tumour cells of primary CRC tissues was significantly lower as compared to adjacent normal tissue. Positive immunoreactivity for IL-17RA and IL-17 were detected in 51.0% and 16.8% of tumour tissues, respectively. Furthermore, negative immunoreactivity of IL-17R was significantly associated with advanced stage according to TNM classifier (p = 0.027), high grade of tumour (p = 0.019), increased depth of tumour invasion (p = 0.023) and vascular invasion (p = 0.039). Positive IL-17 immunoreactivity was associated with advanced stage (p = 0.008) and lymph node metastasis (p = 0.008). Thus, this study suggests that the loss of IL-17RA expression occurs as tumour progresses and this may predict the aggressiveness of tumour whilst expression of IL-17 promotes tumour progression and lymph node metastasis. Thus, loss of IL-17RA could be a useful prognostic biomarker for tumour progression in CRC patients.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s12253-020-00820-4
Publisher: Springer
Keywords: IL-17; IL-17RA; Colorectal carcinoma; Prognostic biomarker; Tumour progression
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 28 Sep 2021 23:42
Last Modified: 28 Sep 2021 23:42
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s12253-020-00820-4
URI: http://psasir.upm.edu.my/id/eprint/86597
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