UPM Institutional Repository

V protein, the virulence factor across the family Paramyxoviridae: a review


May, Ling Tham and Yusoff, Khatijah and Othman, Siti Sarah and Suet, Lin Chia (2019) V protein, the virulence factor across the family Paramyxoviridae: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (3). pp. 73-85. ISSN 0128-7451; ESSN: 2672-7277


Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubulavirus. The members within this family are negative and single-stranded RNA viruses including human and animal pathogens such as measles virus (MeV), Nipah virus (NiV), mumps virus (MuV), Sendai virus (SeV) and Newcastle disease virus (NDV). The V protein is conserved within the family and plays an essential role in viral pathogenicity. Although V proteins of many paramyxoviruses are interferon-antagonists which counteract with the host’s innate immunity, there are still differences in the mode of action of the V protein between different genera or species within the same genera. The strategies to circumvent the host interferon (IFN) pathway can be divided into three general mechanisms; degradation of signal transducers and activators of transcription (STAT) protein, inhibition of phosphorylation of the transcription factor and, inhibition of translocation of STAT proteins into the nucleus. As a result, inhibition of IFN signalling and production promotes viral replication in the host cells. This review highlights the mechanism of the paramyxoviral V protein in evading the host IFN system.

Download File

[img] Text (Abstract)
V protein, the virulence factor across the family Paramyxoviridae a review.pdf

Download (100kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
DOI Number: https://doi.org/10.35118/apjmbb.2019.027.3.08
Publisher: Malaysian Society for Molecular Biology and Biotechnology
Keywords: Paramyxoviridae; Mononegavirales; P gene; V protein; Interferon; Virulence factor
Depositing User: Mr. Sazali Mohamad
Date Deposited: 14 Sep 2020 08:17
Last Modified: 14 Sep 2020 08:17
Altmetrics: http://www.altmetric.com/details.php?domain=psair.upmedu.my&doi=10.35118/apjmbb.2019.027.3.08
URI: http://psasir.upm.edu.my/id/eprint/82701
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item