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Thyroid storm: is there a role for thyroid function test?


Tengku Ibrahim, T. Z. and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna and Nasuruddin, A. N. and Zakaria, M. H. (2019) Thyroid storm: is there a role for thyroid function test? Malaysian Journal of Pathology, 41 (3). pp. 355-358. ISSN 0126-8635


Introduction: Thyroid storm (TS) is an endocrine emergency. Early diagnosis for prompt treatment is essential as it has a high mortality rate. Case report: A 31-year-old lady with underlying hyperthyroidism, dilated cardiomyopathy with severe mitral regurgitation presented with shortness of breath. She was intubated and admitted due to decreasing Glasgow Coma Score. Her blood investigations revealed increased white cell count, raised free thyroxine with suppressed thyroid stimulating hormone, deranged liver, renal and coagulation profiles. As her condition did not improve with initial treatment, plasmapheresis was commenced on day 4. Biochemically, her thyroid function test (TFT) showed improvement; however, she succumbed due to multi-organ failure. Discussion: Plasmapheresis is considered in TS if there is no clinical improvement within 24-48 hours of initial treatment. The improvement in patient's TFT post plasmapheresis signifies its role in treating TS. Unfortunately, there was a delay in commencing plasmapheresis due to haemodynamic instability in this patient.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Malaysian Society of Pathologists
Keywords: Thyroid storm; Hyperthyroidism; Thyroid function test; Plasmapheresis
Depositing User: Mr. Sazali Mohamad
Date Deposited: 14 Sep 2020 08:04
Last Modified: 14 Sep 2020 08:04
URI: http://psasir.upm.edu.my/id/eprint/82639
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