Sensitive surface plasmon resonance performance of cadmium sulfide quantum dots-amine functionalized graphene oxide based thin film towards dengue virus E-protein

Citation

Sheh Omar, Nur Alia and Yap, Wing Fen and Abdullah, Jaafar and Mat Zaid, Mohd Hazani and Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim and Mahdi, Mohd Adzir (2019) Sensitive surface plasmon resonance performance of cadmium sulfide quantum dots-amine functionalized graphene oxide based thin film towards dengue virus E-protein. Optics & Laser Technology, 114. pp. 204-208. ISSN 0030-3992; ESSN: 1879-2545

Abstract

An optical sensor for the dengue virus (DENV) E-protein based on cadmium sulfide quantum dots composited with amine functionalized graphene oxide (CdS-NH2GO) thin film was successfully developed. A specific monoclonal antibodies (IgM) were covalently attached to CdS-NH2GO via EDC/NHS coupling to sense targeted E-proteins. The SPR sensor exhibited an excellent detection limit (0.001 nM/1 pM) with sensitivity of 5.49° nM−1 for the detection of DENV E-protein. The binding affinity, as well as the performance of the Au/CdS-NH2GO/EDC-NHS/IgM film, was successfully obtained at 486.54 nM−1 in detecting DENV E-proteins. These results indicated that the Au/CdS-NH2GO/EDC-NHS/IgM film shows high potential sensitive and stronger binding towards DENV E-protein.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Engineering Faculty of Science Institute of Advanced Technology
DOI Number:	https://doi.org/10.1016/j.optlastec.2019.01.038
Publisher:	Elsevier
Keywords:	Surface plasmon resonance; Binding affinity; DENV E-protein
Depositing User:	Mr. Sazali Mohamad
Date Deposited:	08 Sep 2021 21:41
Last Modified:	08 Sep 2021 21:41
Altmetrics:	http://www.altmetrics.com/details.php?domain=pasir.upm.edu.my&doi=10.1016/j.optlastec.2019.01.038
URI:	http://psasir.upm.edu.my/id/eprint/82088
Statistic Details:	View Download Statistic

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