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Long-term impact of bariatric surgery in diabetic nephropathy


Young, LeAnne and Nor Hanipah, Zubaidah and Brethauer, Stacy A. and Schauer, Philip R. and Aminian, Ali (2019) Long-term impact of bariatric surgery in diabetic nephropathy. Surgical Endoscopy and Other Interventional Techniques, 33 (5). pp. 1654-1660. ISSN 0930-2794 ; ESSN:1432-2218


Background: Bariatric surgery has been shown to improve and resolve diabetes. However, limited literature about its impact on end-organ complications of diabetes is available. The aim of this study was to examine the long-term effect of bariatric surgery on albuminuria. Methods: We studied 101 patients with pre-operative diabetes and albuminuria [defined as urine albumin:creatinine ratio (uACR) > 30 mg/g] who underwent bariatric surgery at an academic center from 2005 to 2014. Results: Fifty-seven patients (56%) were female with a mean age of 53 (± 11) years. The mean pre-operative BMI and glycated hemoglobin (HbA1c) were 43.1 (± 7.6) kg/m2 and 8.4 (± 1.8)%, respectively. The median pre-operative uACR was 80.0 (45.0-231.0) mg/g. Bariatric procedures included Roux-en-Y gastric bypass (n = 75, 74%) and sleeve gastrectomy (n = 26, 26%). The mean follow-up period was 61 (± 29) months. At last follow-up, the mean BMI was 33.8 (± 8.3) kg/m2. The overall glycemic control improved after bariatric surgery. At last follow-up, 73% had good glycemic control (HbA1c < 7%) and 27% met diabetes remission criteria. The mean HbA1c at last follow-up was 6.7 (± 1.0)% and the median uACR was 30 (IQR 7-94) mg/g. Albuminuria improved in 77% and resolved in 51% of patients at long-term. Conclusions: Bariatric surgery has a significantly positive impact on albuminuria in patients with obesity and type 2 diabetes. Our data showed almost an 80% improvement in albuminuria at the short- and long-term period after bariatric surgery.

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Official URL or Download Paper: https://pubmed.ncbi.nlm.nih.gov/30251143/

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s00464-018-6458-8
Publisher: Springer
Keywords: Albuminuria; Bariatric surgery; Diabetes; Gastric bypass; Nephropathy; Sleeve gastrectomy
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 16 Jun 2021 02:34
Last Modified: 16 Jun 2021 02:34
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00464-018-6458-8
URI: http://psasir.upm.edu.my/id/eprint/81246
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