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Development of metal-organic frameworks for biomedical applications - a review


Mostafa, Yousefzadeh Borzehandani and Abdul Malek, Emilia and Abdul Rahman, Mohd Basyaruddin and Mohammad Latif, Muhammad Alif (2019) Development of metal-organic frameworks for biomedical applications - a review. Journal of Multidisciplinary Engineering Science and Technology, 6 (12). art. no. 42353068. pp. 105-116. ISSN 2458-9403


Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs synthesis as well as their toxicological properties. We also highlighted the potential of MOFs as therapeutic agents and nano-MOFs (NMOFs) for biomedical sensing. Water as an alternative media for MOF synthesis showed excellent results in term of particle size, stability and selectivity. Toxicological assessments revealed Fe (III) and MIL-100 as the most promising metal and MOF for medical applications. It was also shown that MOFs are sensitive towards physiological and pathological criteria such as pH, fluorescence and O2. Although many attempts have been made in utilizing MOFs for bio applications, further improvements should be considered before MOFs can become effective therapeutics options.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Publisher: Naci kalkan
Keywords: Metal-organic framework; Green synthesis; Toxicity; Biomedical; Biosensing
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 09 Sep 2020 07:42
Last Modified: 09 Sep 2020 07:42
URI: http://psasir.upm.edu.my/id/eprint/81158
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