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Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor


Citation

Mustapha Kamil, Yasmin and Al-Rekabi, Sura Hmoud and Yaacob, Mohd Hanif and Syahir, Amir and Hui, Yee Chee and Mahdi, Mohd Adzir and Abu Bakar, Muhammad Hafiz (2019) Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor. Scientific Reports, 9. art. no. 13483. pp. 1-10. ISSN 2045-2322

Abstract

The exponential escalation of dengue cases has indeed become a global health crisis. This work elaborates on the development of a biofunctionalized tapered optical fber (TOF) based sensor with the integration of polyamidoamine (PAMAM) dendrimer for the detection of dengue E protein. The dimension of the TOF generated an evanescent feld that was sensitive to any changes in the external medium while the integration of PAMAM promoted more adhesion of bio-recognition molecules; antiDENV II E protein antibodies; that were complementary to the targeted protein. This in return created more active sites for the absorption of DENV II E proteins onto the tapered region. The resolution and detection limit of the sensor are 19.53nm/nM and 1 pM, respectively with Kd=1.02×10−10M.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.1038/s41598-019-49891-7
Publisher: Nature Publishing Group
Keywords: Dengue; Tapered optical fiber; Antibodies; Raman spectroscopy
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 10 Sep 2020 02:49
Last Modified: 10 Sep 2020 02:49
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1038/s41598-019-49891-7
URI: http://psasir.upm.edu.my/id/eprint/81110
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