UPM Institutional Repository

Depression and quality of life in patients with neurological disorder in a Malaysian hospital


Das, Priscilla and Naing, Nyi Nyi and Wan Abdul Jamil, Wan Arfah Nadiah and Naing @ Noor Jan, Khin Ohnmar and Kueh, Yee Cheng and Rasalingam, Kantha (2019) Depression and quality of life in patients with neurological disorder in a Malaysian hospital. East Asian Archives of Psychiatry, 29 (2). pp. 66-70. ISSN 2224-7041; ESSN: 2078-9947


Objective: To investigate association between major depressive disorder (MDD) and quality of life in patients with neurological disorder. Methods: This cross-sectional study was carried out at a Malaysian hospital between April 2016 and December 2016 using convenience sampling. Patients aged ≥18 years with intracranial tumour or other brain disorders were invited to participate. Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life questionnaire version 3.0; diagnosis of MDD was made using Mini International Neuropsychiatric Interview. Results: Of 122 patients approached, 100 (66 women and 34 men) were included (response rate, 93.5%), with a mean age of 45.3 years. The prevalence of MDD in patients with neurological disorder was 30%. Compared with non-depressed patients, patients with MDD had poorer global health status / quality of life (p = 0.003), and reduced physical (p = 0.003), role (p = 0.021), emotional (p < 0.001), cognitive (p = 0.004), and social (p = 0.007) functioning, as well as more symptoms of fatigue (p = 0.004), pain (p < 0.001), dyspnoea (p = 0.033), insomnia (p < 0.001), appetite loss (p = 0.002), constipation (p = 0.034), diarrhoea (p = 0.021), and financial difficulties (p = 0.039). Conclusion: Patients with MDD had reduced quality of life. Fatigue, pain, dyspnoea, insomnia, appetite loss, constipation, diarrhoea, and financial difficulties were prevalent among patients with MDD.

Download File

[img] Text
MDD.pdf - Published Version

Download (106kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.12809/eaap1777
Publisher: Hong Kong Academy of Medicine Press
Keywords: Brain diseases; Brain neoplasms; Depressive disorder, major; Quality of life
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 12 Oct 2020 08:07
Last Modified: 12 Oct 2020 08:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.12809/eaap1777
URI: http://psasir.upm.edu.my/id/eprint/81094
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item