Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor

Citation

Abu Bakar, Muhammad Hafiz and Mahdi, Mohd Adzir and Yaacob, Mohd Hanif and Amir Hamzah, Amir Syahir and Lim, Hong Ngee and Mustapha Kamil, Yasmin (2019) Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor. IEEE Journal of Selected Topics in Quantum Electronics, 25 (1). art. no. 7201008. pp. 1-8. ISSN 1077-260X

Abstract

We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics.

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Official URL or Download Paper: https://ieeexplore.ieee.org/document/8384018

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Engineering
DOI Number:	https://doi.org/10.1109/JSTQE.2018.2846044
Publisher:	Institute of Electrical and Electronics Engineers
Keywords:	Optical fiber sensors; Biophotonics
Depositing User:	Ms. Nuraida Ibrahim
Date Deposited:	12 Oct 2020 07:34
Last Modified:	12 Oct 2020 07:47
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1109/JSTQE.2018.2846044
URI:	http://psasir.upm.edu.my/id/eprint/81089
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