Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system

Citation

Abdelkader, Hassani and Hussain, Siti Aslina and Abdullah, Norhafizah and Kamarudin, Suryani and Rosli, Rozita (2019) Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system. Chemical Engineering & Technology, 42 (9). pp. 1816-1824. ISSN 0930-7516; ESSN: 1521-4125

Abstract

The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy. MgOr was successfully encapsulated into the CS cavity. Results with 3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide indicated that MgOrCSNPs retained their cytotoxic activity against the liver cancer cell line (HepG2) and breast cancer cell line (MCF‐7), and low toxicity against the human cell line (3T3) and human retinal epithelial cell line (ARPE‐19).

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Engineering Institute of Bioscience
DOI Number:	https://doi.org/10.1002/ceat.201800478
Publisher:	WILEY-VCH Verlag
Keywords:	Chitosan; Drug delivery; Encapsulation; Magnesium orotate; Nanoparticles
Depositing User:	Ms. Nuraida Ibrahim
Date Deposited:	14 Oct 2020 21:22
Last Modified:	14 Oct 2020 21:22
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/ceat.201800478
URI:	http://psasir.upm.edu.my/id/eprint/80914
Statistic Details:	View Download Statistic

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