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Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders


Cheah, Pike See and Mason, John O. and Ling, King Hwa (2019) Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders. Neuroscience Research Notes, 2 (1). pp. 1-6. ISSN 2576-828X


The human brain is made up of billions of neurons and glial cells which are interconnected and organized into specific patterns of neural circuitry, and hence is arguably the most sophisticated organ in human, both structurally and functionally. Studying the underlying mechanisms responsible for neurological or neurodegenerative disorders and the developmental basis of complex brain diseases such as autism, schizophrenia, bipolar disorder, Alzheimer’s and Parkinson’s disease has proven challenging due to practical and ethical limitations on experiments with human material and the limitations of existing biological/animal models. Recently, cerebral organoids have been proposed as a promising and revolutionary model for understanding complex brain disorders and preclinical drug screening.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.31117/neuroscirn.v2i1.28
Publisher: Neurotak Publishing
Keywords: Cerebral organoids; 3D culture; Microfluidic platform; Precision medicine
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 15 Oct 2020 22:48
Last Modified: 15 Oct 2020 22:48
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.31117/neuroscirn.v2i1.28
URI: http://psasir.upm.edu.my/id/eprint/80883
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