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Comparison of pathogenesis of Berghei infection in mouse and rats models


Basir, Rusliza and Hassan, Haniza and Zakaria, Zainul Amiruddin and Nordin, Norshariza and Chin, Voon Kin and Lee, Tze Yan and Chong, Wing Chui (2019) Comparison of pathogenesis of Berghei infection in mouse and rats models. Journal of Health and Translational Medicine (JUMMEC), 22 (2). pp. 4-12. ISSN 1823-7339; ESSN: 2289-392X


Background: The cytokine cascade in the immunopathogenesis of malaria infection had been widely studied. However, their specific association with survival and severe infection remained obscure. Methods: The study investigated the cytokine profiles and histopathological features of malaria in the severe infection and survival models by using male ICR mice and male Sprague Dawley rats respectively. Results: The severe model, the infected ICR mice, exhibited a high parasitemia with 100% mortality after peak parasitemia at day 5 post-infection. The survival model, the infected Sprague Dawley rats, showed mild parasitemia with full recovery by day 14 of infection. Both severe and survival models showed similar histopathological severity during peak parasitemia. The severe model produced highly elevated levels of proinflammatory cytokines, TNF-α and IL-1α, and low levels of the anti-inflammatory cytokine, IL-4; while the survival model showed low levels of TNF-α and IL-1α with high levels of IL-4. Conclusion: There were differences in the pathogenesis of the severe and survival models of malaria infection. These could be a basis for immunotherapy of malaria in the future.

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Official URL or Download Paper: https://jummec.um.edu.my/article/view/16835/10562

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: University of Malaya
Keywords: Malaria; Survival and severe models; Cytokines; Immunopathogenesis of malaria
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 09 Nov 2020 14:57
Last Modified: 09 Nov 2020 14:57
URI: http://psasir.upm.edu.my/id/eprint/80783
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