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Infectious hematopoietic necrosis virus: advances in diagnosis and vaccine development


Chean, Yeah Yong and Hui, Kian Ong and Hooi, Chia Tang and Swee, Keong Yeap and Omar, Abdul Rahman and Kok, Lian Ho and Wen, Siang Tan (2019) Infectious hematopoietic necrosis virus: advances in diagnosis and vaccine development. PeerJ, 7. pp. 1-30. ISSN 2167-8359


The aquaculture of salmonid fishes is a multi-billion dollar industry with production over 3 million tons annually. However, infectious hematopoietic necrosis virus (IHNV), which infects and kills salmon and trout, significantly reduces the revenue of the salmon farming industry. Currently, there is no effective treatment for IHNV infected fishes; therefore, early detection and depopulation of the infected fishes remain the most common practices to contain the spread of IHNV. Apart from hygiene practices in aquaculture and isolation of infected fishes, loss of fishes due to IHNV infection can also be significantly reduced through vaccination programs. In the current review, some of the diagnostic methods for IHNV, spanning from clinical diagnosis to cell culture, serological and molecular methods are discussed in detail. In addition, some of the most significant candidate vaccines for IHNV are also extensively discussed, particularly the DNA vaccines.

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Official URL or Download Paper: https://pubmed.ncbi.nlm.nih.gov/31341728/

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.7717/peerj.7151
Publisher: PeerJ
Keywords: DNA vaccine; Diagnosis; Infectious hematopoietic necrosis virus; Rhabdovirus; Vaccine
Depositing User: Azhar Abdul Rahman
Date Deposited: 19 Oct 2020 17:17
Last Modified: 19 Oct 2020 17:17
Altmetrics: http://altmetrics.com-details.php?domain=psair.upm.edu.my&doi= 10.7717/peerj.7151
URI: http://psasir.upm.edu.my/id/eprint/80249
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