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Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians


AbdulRahman, Yakubu and Azlan, Azrina and Loh, Su Peng and Ismail, Irmi Zarina and Md Noor, Sabariah (2019) Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians. Life Sciences, Medicine and Biomedicine, 3 (8). pp. 1-10. ISSN 2600-7207


Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the therapeutic effects of YSS is still unclear. Objective: Therefore, this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55 years old, were recruited for 6-months cross-over trial study. They were randomised equally to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. The diets were switched after an eight-week washout period. Baseline dietary fish intakes were similar in the two groups. Results: Significant differences observed in serum leptin for YSS-baseline group I and salmon-baseline group II (p<0.05). Significant changes were observed in serum P-selectin, sCD40L and IL-1β in YSS-baseline group I (p<0.05) but not in VCAM-1 (p>0.05). Significant decreased were also observed in serum vWF and VCAM-I in salmon/baseline group II (p<0.05), but not in P-selectin, sCD40L and IL-1β (p>0.05). However, there was no significant differences between YSS and salmon (P>0.05) on time and treatment in all variable after 16 week, but there was a significant effect of treatment on sCD40L from YSS and vWF from salmon (p<0.05) Conclusion: Both YSS and salmon could harmonized EPA+DHA into leptin, platelet and endothelial phospholipid membrane to decreased platelet and endothelial cell activation markers which may contribute to the cardioprotective effect of EPA +DHA. Thus, the health benefits of YSS fish “ikan selar” and salmon on leptin and prothrombotic parameter on healthy overweight adults may be similar.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.28916/lsmb.3.8.2019.28
Publisher: Biome Scientia
Keywords: EPA/DHA; Leptin; Platelet and endothelial cells markers; YSS; Salmon
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 30 Jun 2021 10:56
Last Modified: 30 Jun 2021 10:56
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.28916/lsmb.3.8.2019.28
URI: http://psasir.upm.edu.my/id/eprint/79589
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