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Dimethyl sulfoxide and their toxicity


Jamil Abdulwahid Kurdi, Samiaa and Saulol Hamid, Nur Fazila and Ranneh, Yazan and Goh, Yong Meng and Hashim, Zailina (2019) Dimethyl sulfoxide and their toxicity. International Journal For Research In Biology & Pharmacy, 5 (7). pp. 1-10. ISSN 2208-2093


The aim of the present mini-review was to report a toxic effect of dimethyl sulfoxide (DMSO) that has indicated to change the histology of the liver and kidney of rats. DMSO is a powerful co-solvent and often is used in early metabolic studies when compounds are poorly characterized and difficult to become soluble in water. To become soluble, they have to be dissolved in organic lipophilic solvents (vehicles). Following its conventional use, plant extract has been exposed to various intense and sub-acute toxicity studies to legitimize its toxicological security. Normally, DMSO has low fundamental toxicity yet plant extract when dissolved in 10% DSMO can cause noteworthy confined toxic impacts in the liver and kidney of rats. Be that as it may, vehicles currently in use have pleiotropic impacts, which are regularly obscure. Therefore, researchers ought to be cautious in the preparation and storage of substances before they are dispensed to animals. If this is not done, it may lead to accidental adverse effects on the animals and frequently result in inaccurate outcomes. In this mini-review, we summed up data on biological impacts of the DMSO most generally utilized lipophilic medication vehicles. Other than in experimental models, the information, where accessible, are presented on the impacts of solvents in therapeutic use in rodents. All in all, a few suggestions are given on the utilization of medication solvents in tests.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Publisher: Green Publication
Keywords: DMSO; Clinacanthus nutans; Mice; Rat; Toxicity
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 30 Mar 2021 23:14
Last Modified: 30 Mar 2021 23:14
URI: http://psasir.upm.edu.my/id/eprint/79391
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