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Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits


Che Idris, Che Anishas and Siew, Wai Lin and Abdull Razis, Ahmad Faizal (2020) Hypocholesterolaemic and anti-atherogenic effects of palm-based oils (NoveLin I and NoveLin II) in cholesterol-fed rabbits. International Journal of Environmental Research and Public Health, 17 (9). art. no. 3226. pp. 1-10. ISSN 1661-7827; ESSN: 1660-4601


NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.3390/ijerph17093226
Publisher: MDPI
Keywords: NoveLin I; NoveLin II; Palm-based; Cholesterol; Atherosclerosis
Depositing User: Nabilah Mustapa
Date Deposited: 15 Jun 2020 07:26
Last Modified: 15 Jun 2020 07:26
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijerph17093226
URI: http://psasir.upm.edu.my/id/eprint/78159
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