Genotoxicity of Euphorbia hirta: an Allium cepa assay

Citation

Kwan, Yuet Ping and Ibrahim, Darah and Yusuf, Umi Kalsom and Chen, Yeng and Sreenivasan, Sasidharan (2012) Genotoxicity of Euphorbia hirta: an Allium cepa assay. Molecules, 17 (7). pp. 7782-7791. ISSN 1420-3049

Abstract

The potential genotoxic effects of methanolic extracts of Euphorbia hirta which is commonly used in traditional medicine to treat a variety of diseased conditions including asthma, coughs, diarrhea and dysentery was investigated using Allium cepa assay. The extracts of 125, 250, 500 and 1,000 µg/mL were tested on root meristems of A. cepa. Ethylmethanesulfonate was used as positive control and distilled water was used as negative control. The result showed that mitotic index decreased as the concentrations of E. hirta extract increased. A dose-dependent increase of chromosome aberrations was also observed. Abnormalities scored were stickiness, c-mitosis, bridges and vagrant chromosomes. Micronucleated cells were also observed at interphase. Result of this study confirmed that the methanol extracts of E. hirta exerted significant genotoxic and mitodepressive effects at 1,000 µg/mL.

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Official URL or Download Paper: https://www.mdpi.com/1420-3049/17/7/7782

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.3390/molecules17077782
Publisher:	MDPI
Keywords:	Genotoxicity; Allium cepa; Ethylmethane sulfonate; Mitotic index; Chromosome aberrations
Depositing User:	Nabilah Mustapa
Date Deposited:	01 Jun 2020 03:12
Last Modified:	01 Jun 2020 03:12
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules17077782
URI:	http://psasir.upm.edu.my/id/eprint/77988
Statistic Details:	View Download Statistic

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