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Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome


Lee, Yee Lin and Abu Hassan, Hasyma and Ismail, Intan Hakimah (2020) Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 323-325. ISSN 1675-8544; ESSN: 2636-9346


Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition which is important for clinicians to recognize as it has a high mortality rate and can result in significant neurological morbidities. It presents as acute encephalopathy with radiological findings of symmetrical brain lesions in bilateral thalami, putamen, brain stem tegmentum, internal capsule, periventricular white matter and cerebellar medulla. Intravenous methylprednisolone is the mainstay of treatment. Immunoglobulin therapy and therapeutic hypothermia may be used as adjunctive therapy in cases with severe clinical and neuroradiological presentation. We present a case of severe ANEC and discuss the clinical manifestations, neuroimaging and management options.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Acute encephalopathy; Acute necrotizing encephalopathy of childhood; Methylprednisolone
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 17:49
Last Modified: 04 May 2020 17:49
URI: http://psasir.upm.edu.my/id/eprint/77949
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