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Stealth coating of nanoparticles in drug-delivery systems


Citation

Fam, See Yee and Chee, Chin Fei and Yong, Chean Yeah and Ho, Kok Lian and Abdul Razak, Mariatulqabtiah and Tan, Wen Siang (2020) Stealth coating of nanoparticles in drug-delivery systems. Nanomaterials, 10 (4). art. no. 787. pp. 1-18. ISSN 2079-4991

Abstract

Nanoparticles (NPs) have emerged as a powerful drug-delivery tool for cancer therapies to enhance the specificity of drug actions, while reducing the systemic side effects. Nonetheless, NPs interact massively with the surrounding physiological environments including plasma proteins upon administration into the bloodstream. Consequently, they are rapidly cleared from the blood circulation by the mononuclear phagocyte system (MPS) or complement system, resulting in a premature elimination that will cause the drug release at off-target sites. By grafting a stealth coating layer onto the surface of NPs, the blood circulation half-life of nanomaterials can be improved by escaping the recognition and clearance of the immune system. This review focuses on the basic concept underlying the stealth behavior of NPs by polymer coating, whereby the fundamental surface coating characteristics such as molecular weight, surface chain density as well as conformations of polymer chains are of utmost importance for efficient protection of NPs. In addition, the most commonly used stealth polymers such as poly(ethylene glycol) (PEG), poly(2-oxazoline) (POx), and poly(zwitterions) in developing long-circulating NPs for drug delivery are also thoroughly discussed. The biomimetic strategies, including the cell-membrane camouflaging technique and CD47 functionalization for the development of stealth nano-delivery systems, are highlighted in this review as well.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/nano10040787
Publisher: MDPI
Keywords: Nanoparticles; Polymer; Stealth; Drug delivery; Opsonization; Phagocytosis
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:54
Last Modified: 04 May 2020 16:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/nano10040787
URI: http://psasir.upm.edu.my/id/eprint/77754
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