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Palladium and copper catalyzed Sonogashira cross coupling has been an excellent methodology for C-C bond formation for 17 years: a review


Citation

Kanwal, Iram and Mujahid, Aqsa and Rasool, Nasir and Rizwan, Komal and Malik, Ayesha and Ahmad, Gulraiz and Shah, Syed Adnan Ali and Rashid, Umer and Mad Nasir, Nadiah (2020) Palladium and copper catalyzed Sonogashira cross coupling has been an excellent methodology for C-C bond formation for 17 years: a review. Catalysts, 10 (4). art. no. 443. pp. 1-48. ISSN 2073-4344

Abstract

Sonogashira coupling involves coupling of vinyl/aryl halides with terminal acetylenes catalyzed by transition metals, especially palladium and copper. This is a well known reaction in organic synthesis and plays a role in sp2-sp C-C bond formations. This cross coupling was used in synthesis of natural products, biologically active molecules, heterocycles, dendrimers, conjugated polymers and organic complexes. This review paper focuses on developments in the palladium and copper catalyzed Sonogashira cross coupling achieved in recent years concerning substrates, different catalyst systems and reaction conditions.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Institute of Advanced Technology
DOI Number: https://doi.org/10.3390/catal10040443
Publisher: MDPI
Keywords: Cross coupling; Copper; Palladium; Transition; Sonogashira
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:54
Last Modified: 04 May 2020 16:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/catal10040443
URI: http://psasir.upm.edu.my/id/eprint/77749
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