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Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice


Ong, Hui Ming and Ahmad Azmi, Ahmad Farhan and Leong, Sze Wei and Abas, Faridah and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2016) Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice. In: Malaysia International Biology Symposium 2016, 26-27 Oct. 2016, PICC, Putrajaya, Malaysia. (p. 100).


A novel compound from diarylpentanoids analogues, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, was evaluated on its antinociceptive activity in mice through acetic acid-induced abdominal constriction test. Antinociception of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol was indicated by the reduction in the mean of the number of abdominal constrictions in the test groups compared to the control group. Acetylsalicylic acid (ASA, 100 mg/kg) was used as reference drugs while control group only received vehicle (5% DMSO: 5% Tween 20: 90% Distilled water) that used to dissolve the compound. The mice that received intraperitoneal injections of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol at 0.1, 0.3, 1.0 and 3.0 mg/kg showed 48.34%, 60.79%, 90.07% and 98.54% of inhibition respectively. Acetic acid injection in mice peritoneal cavity can promote the release of many inflammatory mediators such as prostaglandin, bradykinin, substance P, TNF-α, IL-1β, IL-8 and other mediator, which will then stimulate primary afferent neurons to enhance the release of aspartate and glutamate. Hence, the result obtained from this chemical model of nociception suggests that the antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol may be linked partly to the inhibition of the inflammatory mediators.

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Food Science and Technology
Faculty of Medicine and Health Science
Institute of Bioscience
Publisher: Department of Biology, Faculty of Science, Universiti Putra Malaysia
Keywords: Acetic acid-induced abdominal constriction test; Antinociceptive activity; Diarylpentanoids analogues
Depositing User: Nabilah Mustapa
Date Deposited: 15 Apr 2020 16:34
Last Modified: 15 Apr 2020 16:34
URI: http://psasir.upm.edu.my/id/eprint/77586
Statistic Details: View Download Statistic

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