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Nutrients and oxidative stress: friend or foe?


Tan, Bee Ling and Mohd Esa, Norhaizan and Liew, Winnie Pui Pui (2018) Nutrients and oxidative stress: friend or foe? Oxidative Medicine and Cellular Longevity, 2018. art. no. 9719584. pp. 1-24. ISSN 1942-0900; ESSN: 1942-0994


There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF-κB-) mediated cell signaling pathways. Dietary carbohydrates, animal-based proteins, and fats are important to highlight here because they may contribute to the long-term consequences of nutritionally mediated inflammation. Oxidative stress is a central player of metabolic ailments associated with high-carbohydrate and animal-based protein diets and excessive fat consumption. Obesity has become an epidemic and represents the major risk factor for several chronic diseases, including diabetes, cardiovascular disease (CVD), and cancer. However, the molecular mechanisms of nutritionally mediated oxidative stress are complex and poorly understood. Therefore, this review aimed to explore how dietary choices exacerbate or dampen the oxidative stress and inflammation. We also discussed the implications of oxidative stress in the adipocyte and glucose metabolism and obesity-associated noncommunicable diseases (NCDs). Taken together, a better understanding of the role of oxidative stress in obesity and the development of obesity-related NCDs would provide a useful approach. This is because oxidative stress can be mediated by both extrinsic and intrinsic factors, hence providing a plausible means for the prevention of metabolic disorders.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2018/9719584
Publisher: Hindawi Publishing Corporation
Keywords: Nutrients; Oxidative stress; Nutritionally mediated inflammation; Nutritionally mediated oxidative stress
Depositing User: Mr. Sazali Mohamad
Date Deposited: 04 Dec 2019 05:15
Last Modified: 04 Dec 2019 05:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2018/9719584
URI: http://psasir.upm.edu.my/id/eprint/75103
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