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Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies


Faudzi, Hanis and Faroque, Habibah and Suet, Lin Chia and Abdul Rahim, Raha and Othman, Siti Sarah (2018) Lactococcus lactis: LAB model organism for bacteria-mediated therapeutic strategies. Asia-Pacific Journal of Molecular Biology and Biotechnology, 26 (1). pp. 1-10. ISSN 0128-7451


Lactococcus lactis is a well-characterized, food-grade lactic acid bacterium (LAB) with generally recognized as safe (GRAS) status. Better understanding of this bacterium at a molecular level has led to the development of unprecedented genetic tools that enable the expression of heterologous proteins. Subsequently, the ability of L. lactis to express and deliver these proteins to eukaryotic hosts presents a promising approach to achieve potent treatments for various diseases. Here, we have reviewed the characteristics of L. lactis and the expression systems established for this LAB model organism. We also described the experimental applications of L. lactis in disease therapy, especially its role as a vector in vaccination strategies.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
DOI Number: https://doi.org/10.35118/apjmbb.2018.026.1.01
Keywords: Bactofection; Lactic acid bacteria; Lactococcus lactis; Vaccine; Vector
Depositing User: Mr. Sazali Mohamad
Date Deposited: 17 Mar 2020 08:12
Last Modified: 17 Mar 2020 08:12
Altmetrics: http://www.altmetric.com/details.php?domain=psair.upmedu.my&doi= 10.35118/apjmbb.2018.026.1.01
URI: http://psasir.upm.edu.my/id/eprint/74817
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