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The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis


Citation

Bello, Ramatu Omenesa and Chin, Voon Kin and Abd Rachman Isnadi, Mohammad Faruq and Abd Majid, Roslaini and Abdullah, Maizaton Atmadini and Lee, Tze Yan and Zakaria, Zainul Amiruddin and Hussain, Mohd Khairi and Basir, Rusliza (2018) The role, involvement and function(s) of interleukin-35 and interleukin-37 in disease pathogenesis. International Journal of Molecular Sciences, 19. art. no. 1149. pp. 1-28. ISSN 1661-6596; EISSN: 1422-0067

Abstract

The recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics, mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/ijms19041149
Publisher: MDPI
Keywords: Cytokines; Interleukin-35; Interleukin-37; Pathogenesis
Depositing User: Nida Hidayati Ghazali
Date Deposited: 02 Apr 2020 07:30
Last Modified: 02 Apr 2020 07:30
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms19041149
URI: http://psasir.upm.edu.my/id/eprint/74275
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