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The 'checkmate' for iron between human host and invading bacteria: chess game analogy


Citation

Kalidasan, V. and Joseph, Narcisse and Subbiah, Suresh Kumar and Awang Hamat, Rukman and Neela, Vasantha Kumari (2018) The 'checkmate' for iron between human host and invading bacteria: chess game analogy. Indian Journal of Microbiology, 58 (3). 257 - 267. ISSN 0046-8991; ESSN: 0973-7715

Abstract

Iron is an essential nutrient for all living organisms with critical roles in many biological processes. The mammalian host maintains the iron requirements by dietary intake, while the invading pathogenic bacteria compete with the host to obtain those absorbed irons. In order to limit the iron uptake by the bacteria, the human host employs numerous iron binding proteins and withholding defense mechanisms that capture iron from the microbial invaders. To counteract, the bacteria cope with the iron limitation imposed by the host by expressing various iron acquisition systems, allowing them to achieve effective iron homeostasis. The armamentarium used by the human host and invading bacteria, leads to the dilemma of who wins the ultimate war for iron.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s12088-018-0740-2
Publisher: Springer Verlag
Keywords: Iron; Host–pathogen; Iron homeostasis; Host defense; Siderophore; Microbial iron acquisition
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 26 Apr 2020 17:11
Last Modified: 26 Apr 2020 17:11
Altmetrics: https://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s12088-018-0740-2
URI: http://psasir.upm.edu.my/id/eprint/74104
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