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Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients


Citation

Jabir, Rafid Salim and Gwo, Fuang Ho and Ahmad Annuar, Muhammad Azrif and Stanslas, Johnson (2018) Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients. Biomarkers, 23 (2). 142 - 146. ISSN 1354-750X, ESSN: 1366-5804

Abstract

Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Objective: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians). Materials and methods: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established. Results: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash. Conclusions: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1080/1354750X.2017.1334152
Publisher: Taylor & Francis
Keywords: AAG; Adverse events; Docetaxel; Oral mucositis; Rash
Depositing User: Nida Hidayati Ghazali
Date Deposited: 08 Jun 2020 18:50
Last Modified: 08 Jun 2020 18:50
Altmetrics: https://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/1354750X.2017.1334152
URI: http://psasir.upm.edu.my/id/eprint/73537
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