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Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice


Mohammed Alitheen, Noorjahan Banu and Long, Kamariah and Beh, Boon Kee and Mohamad, Nurul Elyani and Swee, Keong Yeap and Ky, Huynh and Kian, Lam Lim and Wan, Yong Ho and Sharifuddin, Shaiful Adzni (2018) Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice. BMC Complementary and Alternative Medicine, 18 (1). pp. 1-9. ISSN 1472-6882


Background: Coconut water has been commonly consumed as a beverage for its multiple health benefits while vinegar has been used as common seasoning and a traditional Chinese medicine. The present study investigates the potential of coconut water vinegar in promoting recovery on acetaminophen induced liver damage. Methods: Mice were injected with 250 mg/kg body weight acetaminophen for 7 days and were treated with distilled water (untreated), Silybin (positive control) and coconut water vinegar (0.08 mL/kg and 2 mL/kg body weight). Level of oxidation stress and inflammation among treated and untreated mice were compared. Results: Untreated mice oral administrated with acetaminophen were observed with elevation of serum liver profiles, liver histological changes, high level of cytochrome P450 2E1, reduced level of liver antioxidant and increased level of inflammatory related markers indicating liver damage. On the other hand, acetaminophen challenged mice treated with 14 days of coconut water vinegar were recorded with reduction of serum liver profiles, improved liver histology, restored liver antioxidant, reduction of liver inflammation and decreased level of liver cytochrome P450 2E1 in dosage dependent level. Conclusion: Coconut water vinegar has helped to attenuate acetaminophen-induced liver damage by restoring antioxidant activity and suppression of inflammation.

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Official URL or Download Paper: https://pubmed.ncbi.nlm.nih.gov/29940935/

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1186/s12906-018-2199-4
Publisher: BioMed Central
Keywords: Cocos nucifera; Paracetamol; Phenolic; Acetification; Inflammation
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 10 Nov 2020 07:37
Last Modified: 10 Nov 2020 07:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/s12906-018-2199-4
URI: http://psasir.upm.edu.my/id/eprint/73431
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