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Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle


Mark Hiew, Wen Han and A. A., Megahed and Constable, Peter D. (2018) Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle. Journal of Veterinary Internal Medicine, 32 (2). 846 - 852. ISSN 1939-1676; ESSN: 0891-6640


Background: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. Objectives: To evaluate the relationship between plasma [FRA] and glucose concentration ([gluc]) as well as indices of energy balance during early lactation in dairy cattle, and to characterize the influence of plasma total protein concentration ([TP]) and albumin concentration ([albumin]) on [FRA]. Animals: Convenience sample comprising 103 periparturient Holstein-Friesian cattle. Methods: Plasma [gluc], [TP], [albumin], and other clinicopathologic indices of energy status were determined periodically from Day 4 postpartum. Body condition score (BCS) was assessed, and backfat thickness (BFT) and longissimus dorsi muscle thickness (LDT) were measured ultrasonographically. Plasma [FRA] was measured at approximately 28 days postpartum. Associations between plasma [FRA] and study variables were evaluated using Spearman's rho and stepwise forward linear regression. statistical significance was declared at P < 0.05. Results: A positive association was detected between plasma [FRA] and mean plasma [gluc] from Days 4-28 postpartum (rs = +0.36, P < 0.001), and between plasma [FRA] and LDT (rs = +0.28, P = 0.007), BCS (rs = +0.23, P = 0.029), and BFT (rs = +0.21, P = 0.043). Multivariable regression identified a positive association between plasma [FRA] and mean plasma [gluc] and [albumin] from Days 4-28 postpartum. Correcting plasma [FRA] for [albumin] improved the association (rs = +0.46, P < 0.001) between plasma [FRA] and mean plasma [gluc]. Conclusions and clinical importance: Plasma [FRA] does not provide a clinically useful method for quantifying the magnitude of hypoglycemia or negative energy balance in dairy cows during early lactation.

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Official URL or Download Paper: https://pubmed.ncbi.nlm.nih.gov/29424465/

Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1111/jvim.15049
Publisher: Wiley-Blackwell
Keywords: Glycated protein; Hyperketonemia; Hypoglycemia
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 10 Nov 2020 07:28
Last Modified: 10 Nov 2020 07:28
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1111/jvim.15049
URI: http://psasir.upm.edu.my/id/eprint/73423
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