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Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review


Abdull Razis, Ahmad Faizal and Arumugam, Asvinidevi (2018) Apoptosis as a mechanism of the cancer chemopreventive activity of glucosinolates: a review. Asian Pacific Journal of Cancer Prevention, 19 (6). 1439 - 1448. ISSN 1513-7368; ESSN: 2476-762X


Cruciferous vegetables are a rich source of glucosinolates that have established anti-carcinogenic activity. Naturally-occurring glucosinolates and their derivative isothiocyanates (ITCs), generated as a result of their enzymatic degradation catalysed by myrosinase, have been linked to low cancer incidence in epidemiological studies, and in animal models isothiocyanates suppressed chemically-induced tumorigenesis. The prospective effect of isothiocyanates as anti-carcinogenic agent has been much explored as cytotoxic against wide array of cancer cell lines and being explored for the development of new anticancer drugs. However, the mechanisms of isothiocyanates in inducing apoptosis against tumor cell lines are still largely disregarded. A number of mechanisms are believed to be involved in the glucosinolate-induced suppression of carcinogenesis, including the induction of apoptosis, biotransformation of xenobiotic metabolism, oxidative stress, alteration of caspase activity, angiogenesis, histone deacytylation and cell cycle arrest. The molecular mechanisms through which isothiocyanates stimulate apoptosis in cancer cell lines have not so far been clearly defined. This review summarizes the underlying mechanisms through which isothiocyanates modify the apoptotic pathway leading to cell death.

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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.22034/APJCP.2018.19.6.1439
Publisher: Asian Pacific Organization for Cancer Prevention
Keywords: Cruciferous vegetables; Glucosinolates; Isothiocyanates; Chemoprevention; Apoptosis
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 30 Nov 2020 07:54
Last Modified: 30 Nov 2020 07:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.22034/APJCP.2018.19.6.1439
URI: http://psasir.upm.edu.my/id/eprint/73173
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